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other than direct blockade by a DAT inhibitor) to regulate the activity of DAT and dopaminergic neurotransmission, and a potential target site for future development of ADHD treatments

An 8-week double-blind randomized placebo-controlled trial in 62 patients with PWS demonstrated an improvement of hyperphagiaevaluated as behavior and severity scores by Dykens Hyperphagia Questionnaireafter Topiramate group versus placebo group, with no effects on BMI [95]

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