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Description

Scientific & Chemical Identification CAS Number: 121062-08-6 Molecular Formula: CHNO Molecular Weight (M.W.): ~1024.18 g/mol Amino Acid Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH Synonyms: Melanotan II, MT-II Peptide Mechanism & Receptor Activity Melanotan-II acts as a non-selective agonist at melanocortin receptors (MC1R, MC3R, MC4R, and MC5R) , mimicking certain effects of endogenous -MSH in research models

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Interference with epithelial barrier integrity (e.g., by pathogenic microbes or drugs) leads to enhanced gut permeability and enables translocation of previously confined (and potentially harmful) microorganisms into the tissue and to distal locations including secondary lymph nodes and liver, where they trigger inflammatory responses 2,3,4

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