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David Sinclair, a leading voice in longevity research, has stated: NAD+ is the closest we've gotten to a fountain of youth.[2] His research highlights how NAD+ activates pathways that mimic caloric restriction, a known extender of lifespan in models

The difference is subtle but important: a facilitator helps increase lean mass more directly, whereas an optimizer affects peripheral areas related to the muscle-building process

This connection, often called the "gut-brain axis," has been the subject of increasing research

This makes GHK-Cu the outlier: the one compound of the three with meaningful clinical grounding, albeit primarily for skin and scar outcomes rather than deep surgical repair