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Since the reduction of glucose concentrations with the classic treatments in diabetes has not given the expected results in terms of cardiovascular protection, the therapeutic strategy with the new antidiabetic drugs such GLP-1 RAs should now focus on the modification of vascular risk factors [3]

SGLT2i) and other newer GLP-1RA medications such as the dual GIP and GLP-1RA medications (tirzepatide and mazdutide) on their effectiveness in ASCVD risk reduction remain lacking

[17] [18] [19] Biological functions [edit] Circadian rhythm [edit] In mammals, melatonin is critical for the regulation of sleepwake cycles, or circadian rhythms