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The absolute risk increase is approximately 25 additional events per 10,000 person-years
We need to see how patients fare over several years, not just several months, to truly understand the risk-benefit profile before we can determine its ultimate place in treatment. Having medications like eloralintide, which work through a different mechanism, may provide a vital alternative and increase our ability to personalize treatment for the individual
A 2025 randomized, double-blind, placebo-controlled trial published in Clinical Nutrition found that 15 mg/day of hydroxytyrosol improved antioxidant and anti-inflammatory status in overweight individuals with prediabetes over 16 weeks, while preserving insulin sensitivity (Moratilla-Rivera et al., 2025)
During times of energy scarcity (dieting), conserving fuel and minimizing maintenance costs is a survival advantage
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