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This uncoupling is clinically relevant because it suggests the bone density changes seen in the Hansen trial are not simply a transient effect of weight loss but may reflect a direct or indirect metabolic effect of GLP-1 receptor activation on bone turnover

The model pairs the Mifflin-St Jeor equation for energy burn with a deliberately conservative drug-effect assumption of about 0.5 percent of body weight per week, applied on top of whatever calorie deficit your inputs produce

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These figures come from different studies, so direct comparison should be made with caution