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These modifications extend its plasma half-life to approximately one week in vivo by facilitating albumin binding and reducing renal clearance, making it a compound of significant interest in metabolic and cardiovascular research
In the SURMOUNT-5 trial (comparing tirzepatide to semaglutide at weight-loss doses), more people discontinued semaglutide due to side effects (5.6%) than tirzepatide (2.7%)
The benefits beyond weight are real, and mostly still early Weight loss is the breakthrough, but it isn't the whole story
The genetic risk factor is present in 1 in 350 boys, only 2 to 4 percent of whom have autism
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