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Some mechanisms, such as mechanical stress caused by carrying excess weight, are self-explanatory, while others involve complex changes in hormones and metabolism

These medications mimic the bodys natural glucagon-like peptide-1 hormone, which helps regulate appetite and blood sugar

These drugs require individualized dosing and titration to achieve therapeutic plasma levels while avoiding adverse effects such as sedation, dizziness, or long-term complications like hepatic dysfunction

A later FDA approval expanded its use to adults with obesity and moderate to severe obstructive sleep apnea when paired with a reduced-calorie eating plan and physical activity