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A number of studies have revealed that exosomes can regulate the function of target cells by secreting their contents into the TME, using crosstalk, and/or influencing major tumor-related pathways, including EMT, CSCs, angiogenesis, and metastasis involving several cell types (Ha et al., 2016
However, unlike GIP, GLP-1 has not been found to have a direct role in fat deposition in adipose tissues [16]
therefore, the short-term efficacy benefits seen in the present analysis are likely to be associated with further benefits over patients lifetimes
Strikingly, the levels of GLP-1 were significantly higher only in the ampicillin- and vancomycin-treated mice than in SPF mice but not in metronidazole- and neomycin-treated mice (Fig
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