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How receptors respond to continuous stimulation When a GLP-1 agonist binds continuously to the receptor, the cell initiates a protective response
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The pharmacokinetics of LY3437943 (retatrutide) support once-weekly administration due to an elimination half-life of approximately 6 days. Jastreboff AM et al., Nature Medicine, 2023 This extended half-life is made possible by attaching a fatty acid chain to the peptide, allowing it to bind to albumin a common protein in your blood that acts like a slow-release carrier
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Aranarochana A, Sirichoat A, Pannangrong W et al (2021) Melatonin Ameliorates valproic acid-induced neurogenesis impairment: The role of oxidative stress in adult rats
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