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Just like the story of Goldilocks and the Three Bears only one bowl of porridge is just right the extremes of too hot (too high IGF-1) and too cold (too low) are definitely not preferable
A double-blind, randomized, placebo-controlled trial in 130 PCOS patients showed the combination of letrozole plus 1,200 mg NAC per day resulted in more follicles greater than 18 mm in diameter (a size associated with greater likelihood of ovulation) after five days than letrozole alone or placebo
You are unlikely to see any positive impact if you use the medicine for less than three months, and we often recommend patients stay on them for 12-24 months to increase the likelihood of sustained weight loss. Taking the medicine for the long-term helps cement healthier habits eating less, exercising more that increase the odds for permanent improvement after getting off the medicine
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