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Wellness 22 May 2026 6 min read Why do I feel worse after my B12 injection
Different manufacturers can specify slightly different conditions
Fridays offers MIC-B12 injections for those seeking supplemental support as part of a broader health plan
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
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