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Despite promising preclinical data, the critical transition of Cu-MOFs and similar nanoplatforms to clinical application faces hurdles, including scalable fabrication, long-term biodistribution studies, and a comprehensive understanding of potential off-target cuproptosis

In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology

Discovery of direct inhibitors of Keap1Nrf2 proteinprotein interaction as potential therapeutic and preventive agents

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