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The bigger lesson is simple: obesity treatment is chronic care

10.3390/ijms25042146 33 MenzelA.SamoudaH.DohetF.LoapS.ElluluM

What the Gila monster evolved over millions of years, a persistent New York endocrinologist named John Eng recognized in the 1980s as a potential key to unlocking one of medicines most persistent challenges: type 2 diabetes

This effect seems to be mediated by activation of the AMPK/PGC-1a (peroxisome proliferation-activated receptor --coactivator 1a) pathway since lentivirus-induced downregulation of PGC-1 reversed the neuroprotective effect [46, 47]