Direct Autocrine Action of Insulin on -Cells: does It Make Physiological Sense
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In this process, alcohol directly leads to the overgrowth and enrichment of some gut microbiota, such as Actinobacteria , Proteobacteria , Enterobacteriaceae , Corynebacterium and Streptococcus , while the abundance of other gut microbiota subsequently decreases, such as Bacteroidetes and Akkermansia genera of the phyla Verrucomicrobia , Lactobacillus , Ruminococcus , Faecalibacterium and Roseburia of the phylum Firmicutes ( Lactobacilli leads to a reduction in the synthesis of saturated long-chain fatty acids, which in turn accelerates hepatic lipid metabolism, oxidative stress, inflammation and fibrosis, thereby attenuating its protective effect on the liver ( Figure 2 During ALD treatment, strategies to modulate gut microbiota are gradually being recognized, which is closely related to the nonnegligible effects of TCMs and NPs ( Table 1 )