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The action of glutathione reductase proceeds through two distinct half reactions, a reductive reaction followed by an oxidative reaction

The most commonly reported side effects in Phase 2 trials were gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, consistent with the GLP-1 receptor agonist class

[47] Safety and Adverse Effects Common adverse effects of incretin-based therapies include nausea, vomiting, diarrhea, constipation, and abdominal discomfort, particularly during dose escalation

Fresh ginger tea (1 to 2 inches of grated ginger steeped in hot water for 10 minutes) taken 20 to 30 minutes before meals may reduce reflux episodes