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This proposal was based in part on the finding that [GSH]:[GSSG] in the secretory pathway and in microsomal vesicles is similar to the ratio found in redox buffers that are effective for the oxidative folding of proteins in vitro that is, between 1:1 and 3:1 (Bass et al , 2004

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In ALS models, SOD1 mutations do not markedly alter astrocytic baseline states but lower the threshold for reactivity, which sensitizes astrocytes to oxidative, glutamatergic and inflammatory stress and drives exaggerated reactive responses to otherwise moderate insults 80

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