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The particularity of this amino acid is its bifunctionality, and its other essential role is the building up of cellular antioxidant defenses via the biosynthesis of the most conserved and abundant non-enzymatic antioxidant in the cell: glutathione
Our results indicated that neither GHK nor GHK-Cu showed cytotoxic activity at the range of concentrations tested while CuCl 2 and Cu(OAc) 2 showed substantial cytotoxicity to the HaCaT cells at the highest concentration assayed, i.e., at 5800 M, after 30 mins treatment
