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The higher GI side effect rates are essentially the price of more powerful weight loss

The other thing is that patients with diabetes may have autonomic dysfunction, thats a known complication of diabetes, so they dont regulate blood pressure well

Additionally, although the thiolactone form has not been unequivocally identified in vivo , homocysteine could undergo intracellular cyclization into homocysteine thiolactone, which could be a major by-product of impaired homocysteine metabolism (Jakubowski, 1997

When your health is on the line, taking medications and other forms of treatment will always have risks