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Warning signs requiring prompt evaluation include: Rectal bleeding or blood in stool Unexplained weight loss (beyond expected medication effect) Persistent change in bowel habits lasting more than a few weeks New-onset abdominal pain that differs from typical GLP-1 side effects Iron-deficiency anemia These symptoms warrant investigation regardless of medication use, as they may indicate various gastrointestinal conditions requiring diagnosis

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10.1254/jphs.95.19 73 LueticK.SucicM.VlainicJ.HalleZ