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Franks, S
Erythropoietic protoporphyria (EPP): randomized phase 3 trials European Union trial (9 months, five implants): In EPP patients, afamelanotide increased painfree direct sunlight exposure (10:0015:00) with median 6.0 h per patient versus 0.8 h on placebo
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Furthermore, alignment analysis also demonstrated that Asn (N), Gly (G), Arg (R), Pro (P), Thr (T), Tyr (Y), Lys (K), Ala-Ser (AS), Cys-Gly (CG), Phe-Pro (FP), Glu-Pro (EP), Leu-Lys (LK), Lys-Phe (KF), Asn-Gly (NG), Asn-Gln-Phe (NQF), and Trp-Asn-Phe (WNF) residues were strictly conserved in all aligned sequences, indicating their potential functions in enzyme activity and/or stability (Supplementary Figure S3)
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