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The GLP-1 ceiling problem Even with the most effective GLP-1 therapies currently available, a significant proportion of patients do not achieve clinically optimal weight loss outcomes

The overarching material developed and investigated comprises AngIV-based compounds, designed to overcome the limitations of native peptides like AngIV, which suffer from poor metabolic stability and inability to cross the BBB due to their size and hydrophilicity

Wang Y, Wang M, Yin S et al (2015) NeuroPep: a comprehensive resource of neuropeptides