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What you eat beforehand, what you drink afterward, even your body position during administration, all of these factors determine whether 10% or 40% of the active compound actually reaches your bloodstream
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Studies in aged rats show that mitochondrial membrane potential, cardiolipin content, respiratory control ratio, and cellular oxygen uptake are significantly reduced compared to young animals, while oxidative stress markers are elevated
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10.1210/jc.2009-0423 33 KomlosD.ZhuoY.RicuperoC
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