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The Human GLP-1R (Luc) HEK293 Reporter Cell was designed to express both the CREB signaling response element and the full-length human GLP-1R receptor (Uniprot: P43220), which could stimulate luciferase-expressing systems with GLP-1R agonists or glucagon-like peptide 1 (GLP-1)

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FDA-approved GLP-1 peptides such as semaglutide and tirzepatide have the strongest safety data, with GoodRx confirming these prescription-only medications are safe and effective when used as directed, a status consistent with the FDA's approval of tirzepatide for chronic weight management