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Description

J Physiol 282:571582

AMPK, a heterotrimeric kinase composed of catalytic and regulatory / subunits, is a master regulator of hepatic lipid metabolism 22

Its biosynthesis is catalyzed by sphingomyelinase, a phosphodiesterase that hydrolyzes the membrane sphingolipid sphingomyelin (SM) to generate ceramide (Zeidan and Hannun, 2010)