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Description

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Microdosing involves using smaller, more frequent doses rather than the standard weekly protocol

5 l of hemolyzed blood was diluted in 1 ml of potassium phosphate buffer (0.05 M, pH 7.0) with EDTA 0.1 mM, and finally in 10 l of H 2 O 2 (1 M) according to the standard procedure of Beers and Sizer