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Since GSH is not carried inside the cell, exogenously administered GSH is most likely to act by increasing plasma GSH levels reducing luminal oxidative stress and increasing NO bioavailability in patients with endothelial dysfunction (220)
The most frequently reported reactions include: Redness (erythema) at the application site Itching or a tingling/stinging sensation , especially on freshly exfoliated or compromised skin Dryness or mild flaking , sometimes related to the overall formulation rather than the peptide itself Temporary irritation when combined with strong actives These reactions typically resolve on their own or after reducing frequency of use
Therefore, advisable to review necessity for ongoing prescription of thiamine and consider its immediate cessation
(L-Carnitine)
