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Most public enthusiasm comes from animal studies, laboratory findings and personal reports rather than large controlled trials involving people
Why this matters for choice: The additional GIP mechanism is why some patients who do not respond adequately to Wegovy may respond better to Mounjaro a different enough mechanism that partial responders to one may be full responders to the other
Recent metabolomics and animal studies showed that TMAO, an intestinal microbiota-dependent metabolite formed from dietary trimethylamine-containing nutrients such as phosphatidylcholine (PC), choline and carnitine, is linked to coronary artery disease pathogenesis, only in the presence of TMA/TMAO generation and intact gut microbiota 35,46
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
