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Large randomized controlled trials (STEP 1, STEP 2, STEP 3) demonstrated that semaglutide at 2.4 mg weekly produces average weight loss of 1517% of baseline body weight over 68 weeks, with sustained metabolic benefits including improved blood glucose and cardiovascular risk markers

Retatrutide activates three metabolic receptors: GLP-1 (appetite suppression and glucose control), GIP (fat metabolism and insulin regulation), and glucagon (energy expenditure and fat oxidation)

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