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In the study by Segerstolpe, T2D donors exhibited reduced -cell numbers and decreased INS expression, as well as pronounced suppression of FXYD2, a Na,K-ATPase gene associated with -cell function
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Smoking, chronic wound healing, and implications for evidence-based practice
The rapid expansion of the CRISPR toolbox, including Cas9, Cas12, Cas13, base editors, prime editors, and programmable transcriptional regulators, has further broadened the scope of possible genetic interventions, ranging from gene disruption and allele replacement to promoter engineering and multiplex genome editing (Lowder et al., 2015
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