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In the phase 1 study, MariTide showed a weight loss of nearly 15% of initial body weight after 3 months, with results persisting for approximately 5 months after the last dose

Elevated glycine could also be related to modulation of carbamoyl phosphate synthetase 1 (CPS1), the rate-limiting enzyme in the urea cycle that converts GCS generated NH 4 + to carbamoyl phosphate, which has shown to be highly enriched by Kbhb in the liver of fasted mice [37]

Ayer A, Macdonald P, Stocker R