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Efficacy and safety of LY3298176 (Tirzepatide), a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes (Phase 2 trial)

Preclinical studies in obese and diabetic rodent models suggest that GLP-1 receptor agonists enhance spermatogenesis, hormone profiles, and sperm function through two intracellular signaling pathways: cyclic adenosine monophosphate and protein kinase A (cAMP/PKA), and phosphoinositide 3-kinase and protein kinase B (PI3K/Akt)

Microglia expresses some pattern recognition receptors that are engaged by pathogen-associated molecular patterns, triggering microglia activation

Cycle Length: Minimum 12 weeks for titration