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The researches show that in the AtT-20 cell line of USP8-mutated pituitary adenomas, inhibitors targeting USP8 such as DUBs-IN-2 and RA-9 can inhibit the progression of pituitary adenomas by reducing the deubiquitinating enzyme activity of USP8, and the core mechanism and downstream pathways have been clarified [89, 90, 160]

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