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In mouse models, this approach has demonstrated superior performance in overcoming physiological barriers and optimizing oral drug delivery
Evolved proteases X(SS1)a, X(SS1)b and X(SS1)c demonstrated proteolytic activity on PC_SS1 (Extended Data Fig
The mice were divided into three groups and treated with tail vein injections of either saline (Saline), scExe4 donor plasmid loaded LNP alone (Donor), or scExe4 donor plasmid loaded LNP plus Cas9 plasmid loaded LNP (Donor+Cas9)
Diabetes 48:22702276 Yada T, Itoh K, Nakata M (1993) Glucagon-like peptide-1-(736)amide and a rise in cyclic adenosine 3,5-monophosphate increase cytosolic free Ca 2+ in rat pancreatic -cells by enhancing Ca 2+ channel activity
