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In order to gain a better understanding of the role of GLP-1 agonists in ALS and their potential for clinical translation we conducted in vivo pharmacology studies with liraglutide following established guidelines for preclinical testing 11
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Then, glutamate is deaminated to -ketoglutarate by the enzyme GLUD1/glutamate dehydrogenase (GDH) or by several aminotransferases to produce other non-essential amino acids
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