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GHK-Cu and Rosuvastatin Interaction: Safety, Mechanisms, and Clinical Guidance At a glance Direct interaction evidence / none published as of May 2026 GHK-Cu metabolism / peptidase degradation, not CYP-mediated Rosuvastatin metabolism / minimal CYP2C9, primarily OATP1B1/1B3 hepatic uptake Overlapping CYP liability / none identified Copper load concern / low at typical GHK-Cu doses (1-3 mg/day subcutaneous) Rosuvastatin muscle risk / myopathy incidence approximately 0.1% per FDA label Monitoring recommendation / CK at baseline and if symptoms arise

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Management emphasizes consistent lid hygiene, warm compresses, and occasionally topical antibiotics

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