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It effectively stimulates GH release but it also raises cortisol (stress hormone), prolactin (reproductive hormone), and aldosterone (blood pressure regulator), and produces intense hunger (ghrelin-like appetite stimulation). For researchers, these off-target effects create experimental noise
Characterised by Francis and colleagues in the Journal of Molecular Endocrinology in 1992
Nrf2 is the principal transcription factor in charge of protecting cells from oxidative stress through the regulation of cytoprotective genes, including the antioxidant GSH pathway, that controls GSH homeostasis by affecting de novo synthesis
Low growth hormone production is associated with decreased bone mineralization, increased risk of fractures and higher likelihood of developing osteoporosis
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