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Future Drug Discovery, 4 (2), FDD75

Interestingly, we found that host genes involved in the maintenance of epithelial cell-cell junctions such as ZO-1 , JAM-A and E-cadherin were also important for Cryptosporidium growth and female development, producing a significant increase in smaller, less developed, parasites when disrupted, while also having relatively minimal effects on host cell viability

Thus, although we cannot exclude off-target effects, our data suggest that p300/SIRT2 pathway may contribute to the regulation of G6PD activity during IV infection and suggest G6PD as a potential target to control the redox cell environment in virus-infected cells