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Despite considerable progress has been made in pre-clinical and clinical research, it is evident that more targeted therapeutic interventions are needed [3]
These uncouplers may lower ROS because they increase energy expenditure by moving protons across the inner mitochondrial membrane (Minanimo-Muta et al., 2018
13 Another study, comparing oral and sublingual administration of a complex of B12, folate and vitamin B6 also found no significant differences in effect on homocysteine between the two modes of administration
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