Adverse reactions so far reported with these drugs include pancreatic insufficiency (Gier et al., 2012), gallstones (Rehfeld et al., 2018), gastroparesis (Sodhi et al., 2023), non-arteritic anterior ischemic optic neuropathy - NAION (Hathaway et al., 2024) and increase in diabetic retinopathy (Bain et al., 2018)
[1] Primary mechanisms: modulation of the nitric oxide (NO) system via upregulation of eNOS, activation of VEGFR2-Akt-eNOS signaling for angiogenesis, and enhancement of antioxidant defenses (HO-1 upregulation)
However, there are medical weight loss options available today for qualifying patients, including FDA-approved medications and comprehensive lifestyle-based programs
Its just one class of medication: GLP-1s