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Here, sitagliptin prevented fatty liver in both wild-type and glucokinase mice paralleled by decreased expression of sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase-1, and fatty acid synthase, and increased expression of peroxisome proliferator-activated receptor- in the liver

doi:10.1016/j.mam.2008.08.006 2

The typical American Diet, highly processed foods, full of chemicals, together with the high levels of Psychosocial stress in the American lifestyle may be more of a cause of Chronic Fatigue, than anything else