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NICE Guidelines on Using DPP-4 Inhibitors in Type 2 Diabetes NICE NG28 recommends DPP-4 inhibitors as second- or third-line therapy alongside metformin, particularly when hypoglycaemia risk or weight gain is a concern, but prioritises SGLT-2 inhibitors in patients with cardiovascular disease or chronic kidney disease

Suppressing long noncoding RNA OGRU ameliorates diabetic retinopathy by inhibition of oxidative stress and inflammation via miR-320/USP14 axis

Meanwhile, GIP activation allows better sugar processing and insulin regulation

Retatrutide remains investigational with no MHRA or EMA marketing authorisation