Pay in 4 interest-free payments of $6.86 Learn more
Ships within 48 hours · Estimated delivery Aug 31 - Sep 5
Spironolactone Class * Potassium-sparing diuretic * Aldosterone (mineralocorticoid) receptor antagonist Mechanism of Action Spironolactone blocks aldosterone receptors in the distal convoluted tubule and collecting duct, resulting in: * Increased sodium and water excretion * Reduced potassium excretion (potassium retention) * Reduced cardiac and vascular remodeling in heart failure Indications * Heart failure with reduced ejection fraction (HFrEF) * Resistant hypertension * Primary hyperaldosteronism (Conn syndrome) * Ascites due to liver cirrhosis * Edema associated with heart failure or nephrotic syndrome * Polycystic ovary syndrome (PCOS) for hirsutism * Prevention of hypokalemia Dosage Adults * Heart failure: 12.525 mg once daily, titrated as needed * Ascites: 100400 mg daily * Hypertension: 25100 mg daily Adverse Effects Common * Hyperkalemia * Nausea * Dizziness * Fatigue Endocrine Effects * Gynecomastia * Breast tenderness * Erectile dysfunction * Decreased libido * Menstrual irregularities Contraindications * Hyperkalemia * Severe renal impairment * Addison disease * Hypersensitivity to spironolactone Drug Interactions * ACE inhibitors * ARBs * Potassium supplements * Other potassium-sparing diuretics These combinations increase the risk of hyperkalemia
However, when exposed to external stressors such as hyperglycemia, complex dysfunction can lead to increased levels of this physiological process
The cycle lengths discussed online come mainly from research-community protocols rather than controlled KLOW studies
Biomarkers of geno-and cytotoxicity in the native broad-snouted caiman ( Caiman latirostris ): chromosomal aberrations and mitotic index
