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Rebound symptoms include, for example, irritability, crankiness, hyperactivity worse than in the unmedicated state, sadness, crying and in rare cases psychotic episodes
Remarkably, a study by Escribano et al revealed that, when compared with the control group, children with severe AATD showed significantly increased levels of oxidative stress biomarkers and decreased levels of antioxidants, as expressed by lower total and reduced glutathione levels, decreased catalase activity, and increased glutathione peroxidase activity
The doctor may recommend continuing the current dose for a bit longer, increasing the dose, or considering alternative treatment options if semaglutide does not seem to be effective for that individual
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