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In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [2-, 11-, and 30-fold the maximum recommended human dose (MRHD) of 2 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (1-, 2-, and 7-fold MRHD) were administered to the females
Later, Wang et al
developed a nano-carrier based on a PAMAM-G4 core modified with L-serine (S-G-R NPs) for loading the natural antioxidant rosmarinic acid (RA), achieving dual enhancement of its antioxidant efficacy and in vivo utilization
But its clearly a play on the original GLP-1s
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