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This reduction leads to an increase in relaxation times and superparamagnetic blocking temperatures, which are related to a poorer stability of the dispersions and to the appearance of more intense interparticle interactions, respectively

Consider initial therapy at this stage when blood glucose 300 to 350 mg/dL (16.7 to 19.4 mmol/L) and/or HbA1C 10%-12% (86 to 108 mmol/mol), especially if the patient is symptomatic or if catabolic features (eg, weight loss, ketosis) are present, in which case basal insulin + mealtime insulin is the preferred initial regimen

Data from SUSTAIN-6 A large human clinical trial randomised 3,297 participants living with type 2 diabetes to receive semaglutide 1mg (Ozempic) or a placebo for two years

In other words, after a year, participants had regained two-thirds of the weight they had lost previously