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The GIP component appears to moderate the GI effects of the GLP-1 activation, which is the same reason Tirzepatide (dual GLP-1/GIP) is generally better tolerated than Semaglutide (GLP-1 only)
It varies by formula, but many promise anywhere from 8 hours to all day
The peptide stimulates new muscle growth yet avoids developing water retention or other issues related to anabolic steroids
Clinical trials show that patients on semaglutide reduce daily calorie intake by 500800 calories on average, not through restriction but through naturally decreased appetite
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