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In the early adhesion phase, immune defenses are active: neutrophils and M1 macrophages target bacteria via phagocytosis, oxidative bursts, increased antimicrobial peptides (AMPs), reactive oxygen species (ROS), and pro-inflammatory cytokines (IL-1, IL-6, TNF-) and chemokines
CANADA CA2601784, the compound patent for semaglutide in Canada, was scheduled to expire in March 2026, however, due to Novo Nordisks failure to pay the required maintenance fees, the patent has lapsed and Novo Nordisk's market exclusivity for semaglutide in Canada officially ended on January 4, 2026
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