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Red blood cells carry oxygen throughout your body, and a deficiency in B12 can lead to anemia, which causes symptoms such as fatigue, weakness, and pale skin

Some people might also notice mild diarrhea or a feeling of swelling in their body, but these are typically temporary

The combination of GLP-1 and GIP activation is what separates tirzepatide from pure GLP-1 agonists like semaglutide, and clinical data suggests the dual mechanism produces superior weight loss outcomes

For instance, one study notes that people with excess weight or obesity appear to have lower vitamin B12 levels than people who have a body mass index (BMI) in the normal range ( Additional research has observed that people who voluntarily took vitamin B12 supplements gained between 2.517 fewer pounds (1.27.7 kg) over 10 years than those who did not supplement with this vitamin ( Still, such observational studies cannot confirm whether low vitamin B12 levels are what caused the weight gain, nor whether theyre what protected against low levels