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no controlled study has ever compared its oral and subcutaneous bioavailability head-to-head, and no human pharmacokinetic data exist at all
The mechanistic plausibility is strong (NNMT inhibition increases NAD+ without the gastrointestinal side effects of high-dose nicotinamide), and the short-term tolerability profile is excellent, but we mean this sincerely: if you're using this compound for durations beyond what the published trials covered, you are operating in uncharted territory
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Peptides reconstituted with sterile water typically have a shelf life of only 24-48 hours, even when refrigerated
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